†† The proportion of reported vaccine breakthrough infections attributed to variants of concern has also been similar to the proportion of these variants circulating throughout the United States. To date, the age and sex distribution of reported vaccine breakthrough infections reflects the fully vaccinated U.S. The number of COVID-19 cases, hospitalizations, and deaths that will be prevented among vaccinated persons will far exceed the number of vaccine breakthrough cases. However, vaccine breakthrough infections occur in only a small fraction of all vaccinated persons and account for a small percentage of all COVID-19 cases ( 5– 8). ¶ However, during the surveillance period, SARS-CoV-2 transmission continued at high levels in many parts of the country, with approximately 355,000 COVID-19 cases reported nationally during the week of April 24–30, 2021.** Even though FDA-authorized vaccines are highly effective, breakthrough cases are expected, especially before population immunity reaches sufficient levels to further decrease transmission. Sequence data were available from 555 (5%) reported cases, 356 (64%) of which were identified as SARS-CoV-2 variants of concern, § including B.1.1.7 (199 56%), B.1.429 (88 25%), B.1.427 (28 8%), P.1 (28 8%), and B.1.351 (13 4%).Īs of April 30, 2021, approximately 101 million persons in the United States had been fully vaccinated against COVID-19. The median age of patients who died was 82 years (interquartile range = 71–89 years) 28 (18%) decedents were asymptomatic or died from a cause unrelated to COVID-19.
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Among the 995 hospitalized patients, 289 (29%) were asymptomatic or hospitalized for a reason unrelated to COVID-19. Based on preliminary data, 2,725 (27%) vaccine breakthrough infections were asymptomatic, 995 (10%) patients were known to be hospitalized, and 160 (2%) patients died. Among these cases, 6,446 (63%) occurred in females, and the median patient age was 58 years (interquartile range = 40–74 years).
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states and territories as of April 30, 2021. † When possible, genomic sequencing is performed on respiratory specimens that test positive for SARS-CoV-2 RNA ( 9).Ī total of 10,262 SARS-CoV-2 vaccine breakthrough infections had been reported from 46 U.S. State health departments voluntarily report vaccine breakthrough infections to CDC. For this surveillance, a vaccine breakthrough infection is defined as the detection of SARS-CoV-2 RNA or antigen in a respiratory specimen collected from a person ≥14 days after receipt of all recommended doses of an FDA-authorized COVID-19 vaccine. received all recommended doses of an FDA-authorized COVID-19 vaccine) will develop symptomatic or asymptomatic infections with SARS-CoV-2, the virus that causes COVID-19 ( 2– 8).ĬDC is working with state and territorial health departments to investigate SARS-CoV-2 infections among persons who are fully vaccinated and to monitor trends in case characteristics and SARS-CoV-2 variants identified from persons with these infections. Despite the high level of vaccine efficacy, a small percentage of fully vaccinated persons (i.e. The Food and Drug Administration (FDA) has issued Emergency Use Authorizations for three COVID-19 vaccines for use in the United States.* In large, randomized-controlled trials, each vaccine was found to be safe and efficacious in preventing symptomatic, laboratory-confirmed COVID-19 ( 1– 3). IdeaScale also includes links to social networks and third-party sites (for example, Facebook and LinkedIn), which may then use information about your visit to target advertising to you on their websites.COVID-19 vaccines are a critical tool for controlling the ongoing global pandemic. These cookies enable the delivery of interest-based ads that may be relevant to you as a result of your activities on IdeaScale and provide IdeaScale with information (such as where you saw the ad) to help analyze the impact of its advertising campaigns. Marketing cookies advertise IdeaScale services to you elsewhere on the Internet.
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